Hepatitis
Learning goals Differentiate the viral structure, mode of transmission, epidemiology, and risk of chronic infection for viral hepatitis caused by hepatitis A, B, C, D and E Use clinical presentation and laboratory testing, including serology and molecular testing (PCR), to distinguish acute infection, chronic infection, resolved infection, and post-vaccination for hepatitis A, B, and C […]
Introduction to viruses
High-yield summary Viral structure and classification All viruses contain genetic material (DNA or RNA, never both) and a protein capsid. Some viruses have an envelope derived from the host cell membrane. Classification by genetic material: DNA viruses (e.g., Herpesviridae, Adenoviridae) and RNA viruses (e.g., Orthomyxoviridae, Retroviridae). Baltimore Classification groups viruses based on their replication strategy […]
Parasitology 2: GI helminths
Learning goals Compare and contrast the epidemiology, clinical features, diagnosis, treatment and prevention of common intestinal roundworms and tapeworms including Enterobius, Ascaris, Ancylostoma (hookworm), Strongyloides, Taenia solium, Echinococcus, and Diphyllobothrium Describe the pathogenesis and type of anemia related to heavy hookworm infections Describe the epidemiology, pathogenesis, and clinical features of Strongyloides hyperinfection Compare and contrast […]
Introduction to vaccines
High-yield summary Types of vaccines Live Attenuated: Replicates, broad immune response, contraindicated in immunocompromised and pregnancy Inactivated: No replication, safer for immunocompromised and pregnancy Polysaccharide and Conjugate: Capsule-targeted, age-dependent response, T-cell independent/dependent Protein Subunit: Toxoids, VLPs, recombinant proteins Viral Vector: Recombinant expression in vivo, adenovirus/VSV Nucleic Acid: mRNA/DNA vaccines, e.g., COVID-19 vaccines Immunology and […]
Other therapies
Albendazole (Albenza) Class(es) Anthelmintic Clinical use(s) FDA approved: echinococcosis, neurocysticercosis. Off-label/clinical use: Ascariasis, capillaria, clonorchiasis, giardiasis, microsporidia (HIV), hymenolepis nana infection, loa loa, trichuriasis. Mechanism(s) of action Causes parasitic death by binding to colchicine-sensitive site of beta tubulin inhibiting their polymerization into microtubules. Key adverse effects Abdominal pain, headache, abnormal liver function tests, N/V, SJS. […]
Tuberculosis
This is the LP for this topic. Include Antituberculars on this page. This URL may need to change. Public Health may want to link to this page.
Micro-ID sorted by systems
rename this page eventually Could link to these from Learning site system LPs put link to this page on the compendium LP and possibly the thread LP Pages to start from: Disease location page is almost system based Overview of parasites is almost system based Outline of parasite diseases and organism according to site/specimen is […]
Other antibiotics
Clindamycin (Cleocin) Class(es) Lincosamide Clinical use(s) FDA approved: Bacterial disease (severe) Including susceptible infections due to anaerobic and aerobic gram positive organisms. Off-label/clinical use: Acne vulgaris (topical). Mechanism(s) of action Inhibits protein synthesis at the level of the 50S ribosomal subunit. Key adverse effects The most common reported AE is mild to moderate morbilliform-like skin […]
Cephalosporins
Cephalexin (Keflex) Class(es) 1st-generation cephalosporin Clinical use(s) FDA approved: Skin and soft tissue infection, osteomyelitis. Off-label/clinical use: Prophylaxis for bacterial endocarditis. Mechanism(s) of action Binds to penicillin binding proteins in cell wall membrane. Key adverse effects C. diff–associated diarrhea (CDAD), seizures (high doses especially in renal impairment) Key drug/food interactions Concurrent use of loop diuretics […]
Antituberculars
See also in the Micro-ID session guide Isoniazid (INH, Nydrazid) Class(es) Antitubercular agent. Clinical use(s) FDA approved: Active tuberculosis (HIV and non-HIV); inactive tuberculosis (HIV and non-HIV). Off-label/clinical use: Atypical mycobacterial infection; determination of acetylation rate. Mechanism(s) of action Bactericidal. Inhibits synthesis of mycoloic acids, an essential component of the bacterial cell wall. Key adverse […]