Antibiotics: Ribosomal/protein synthesis
Learning goals Compare and contrast the mechanism of action, spectrum of activity, and mechanisms of resistance of the various antibiotics that effect protein synthesis List common clinical uses and key adverse effects of the tetracyclines, macrolides, lincosamide (clindamycin), and oxazolidinones (linezolid) List common clinical uses, and describe the monitoring and key adverse effects of the […]
Tuberculosis
Learning goals Described the unique microbiologic features of mycobacteria their role in infection and pathogenesis and the immunologic response Describe the epidemiology and clinical spectrums associated with the non-tuberculosis mycobacteria, M. avium complex and M. leprae Describe the epidemiology, pathophysiology, natural history, and clinical manifestations of Mycobacterium tuberculosis infections Compare and contrast the pros and […]
Pneumonia
Learning goals Define pneumonia and describe the pathogenesis of lower respiratory infections Compare and contrast the common bacterial causes of pneumonia in the following contexts: community-acquired, health-care-associated, persons with obstructive lung disease, immunocompromise, and aspiration Compare and contrast the clinical and diagnostic findings of typical and atypical community-acquired pneumonia Describe the clinical factors that are […]
Viral lower respiratory infections
Learning goals Describe influenza virus structures, virulence factors, and epidemiology and correlate to concepts of antigenic drift and antigenic shift Compare and contrast the virology, epidemiology, pathogenesis, clinical manifestations, complications, diagnosis, treatment, and prevention of influenza, severe acute respiratory syndrome coronavirus (SARS-CoV), and respiratory syncytial virus (RSV) Describe the common diagnostic methods for respiratory viral […]
Bacterial upper respiratory infections
Learning goals Compare and contrast the epidemiology, clinical features, complications, and approach to management of viral and bacterial causes of pharyngitis Describe the clinical manifestations, microbiologic features, diagnostic approach, and treatment of pharyngitis caused by Streptococcus pyogenes Describe the microbiology, epidemiology, clinical presentation, and approach to management of epiglottitis Describe the microbiology, epidemiology, clinical presentation, […]
Viral upper respiratory infections
Learning goals Compare and contrast the microbiology, epidemiology, and range of clinical syndromes associated with rhinovirus, adenovirus, seasonal coronavirus, and parainfluenza Differentiate acute viral respiratory illness from secondary bacterial infections and describe indications to use antibiotics for upper respiratory infections Describe the pathogenesis, microbiologic etiologies, clinical manifestations, diagnosis, and pharmacologic management of otitis media, otitis […]
Infections in the immunocompromised host
Learning goals Correlate types of opportunistic infections related to specific forms of immunodeficiency (cell-mediated, humoral, innate, adaptive, combined) Describe the epidemiology, clinical presentation, diagnosis, treatment approach, and preventative strategies for the opportunistic infections caused by Pneumocystis jirovecii, JC Virus, and Cytomegalovirus Compare and contrast the nature and degree of immunosuppression and the associated opportunistic infections […]
Antibiotics: Beta-lactams
Learning goals Compare and contrast the mechanism of action, spectrum of activity, main clinical uses, and toxicities of the four main subclasses of beta-lactams Describe the mechanisms of resistance used by gram-positive and gram-negative bacteria against the various beta-lactam antibiotics Name the beta-lactamase inhibitors and describe their role and limitations as an antimicrobial Name beta-lactams […]
Endocarditis
Learning goals Describe the classification, predisposing factors, pathophysiology, clinical manifestations, and diagnosis of infective endocarditis (IE) Compare and contrast the common microbiologic causes for acute, subacute, native, and prosthetic valve endocarditis Describe the pharmacologic treatment of infective endocarditis and conditions where surgery is considered Required study materials These are required materials that will help maximize […]
Gram-positive cocci
Learning goals Classify staphylococci and streptococci species according to their microbiologic properties (morphologic features, chemical and/or antigenic identification, and antimicrobial resistance mechanisms) Compare and contrast the pathogenesis, virulence factors, and clinical presentation of infections due to Staphylococcus aureus and coagulase negative staphylococcus Compare and contrast the environmental niches and most common clinical diseases associated with […]