Bone and joint infections

Learning goals Describe the microbiologic agents of bone and joint infections, including age-specific and risk-factor-related pathogens Describe the pathophysiology of osteomyelitis and septic arthritis in terms of risk factors, routes of infection, and anatomic sites Describe the clinical manifestations and diagnostic approach for the different clinical forms of osteomyelitis (acute, chronic, diabetic foot infection) Describe […]

Miscellaneous antibiotics

Learning goals Compare and contrast the mechanism of action and spectrum of activity of the glycopeptides (e.g., vancomycin), the lipopeptides (e.g., daptomycin), and beta-lactams Describe the common clinical uses, adverse effects, and monitoring for vancomycin and daptomycin Describe the mechanism of action, spectrum of activity, common clinical uses, and adverse effects of the fluoroquinolones Describe […]

The use of interim analysis during a randomized controlled trial

In this MEDSCHLR 500, we will discuss the findings from the HIV Prevention Trials Network (HPTN) 052 trial, which showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked infections caused by human immunodeficiency virus type 1 (HIV-1). Learning goals Describe the use of interim analysis during a clinical trial Describe the function […]

The use of interim analysis during a randomized controlled trial (Facilitator)

In this MEDSCHLR 500, we will discuss the findings from the HIV Prevention Trials Network (HPTN) 052 trial, which showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked infections caused by human immunodeficiency virus type 1 (HIV-1). Learning goals Describe the use of interim analysis during a clinical trial Describe the function […]

Spirochetes

Learning goals Describe the distinctive microbiologic and pathogenic features of spirochetes Describe the epidemiology, clinical features, complications, diagnosis, and treatment of leptospirosis Compare and contrast the epidemiology, clinical features, cardinal clinical findings, and treatment for primary, early, and late stage Lyme disease Describe the stages of syphilis including clinical manifestations, interpretation of diagnostic tests, and […]

Clinical research and conflict of interests

Learning goals Demonstrate respectful, constructive, adaptive interactions with peers and/or facilitators, including punctual attendance, advanced preparation, professionalism, and giving and receiving feedback Understand the dominant approach to Justice in the United States Apply the basic elements of Rawls’ theory of ā€œJustice as Fairnessā€ to Health Care Identify key points of dispute raised by critiques of […]

Clinical research and conflict of interests (Facilitator)

Learning goals Demonstrate respectful, constructive, adaptive interactions with peers and/or facilitators, including punctual attendance, advanced preparation, professionalism, and giving and receiving feedback Understand the dominant approach to Justice in the United States Apply the basic elements of Rawls’ theory of ā€œJustice as Fairnessā€ to Health Care Identify key points of dispute raised by critiques of […]

Development and utilization of clinical guidelines

In previous sessions you have learned to read and critically appraise primary research papers. This session turns to a different type of document: the clinical practice guideline. Guidelines occupy a unique place in medicine—they are how research gets translated into decisions at the bedside. Understanding where a guideline comes from, whether it was built well, […]

Development and utilization of clinical guidelines (Facilitator)

In previous sessions you have learned to read and critically appraise primary research papers. This session turns to a different type of document: the clinical practice guideline. Guidelines occupy a unique place in medicine—they are how research gets translated into decisions at the bedside. Understanding where a guideline comes from, whether it was built well, […]