Clinical connection: Hunting for a Diagnosis
This short video (~9 min.) from the New England Journal of Medicine (NEJM) highlights the effects of climate change on health through an illustrative patient case.
Source: Leslie Chang, M.D., Debra Malina, Ph.D., Lisa Rosenbaum, M.D., Caren Solomon, M.D., M.P.H., and Timothy Vining. Hunting for a Diagnosis. N Engl J Med 2023;388: e16. Published February 15, 2023.
Additional exploration
Lyme Disease
- Caused by the spirochete bacteria: Borrelia burgdorferi.
- Transmitted by Ixodes scapularis (East) and Ixodes pacificus (West).
- Early Signs and Symptoms (3–30 days post-tick bite):
- Fever.
- Chills.
- Fatigue.
- Erythema.
- Migrans rash in 70–80% patients.
- Later signs and symptoms (days to months post-tick bite):
- Multiple EM rashes.
- Meningitis.
- Bell’s Palsy.
- Carditis.
- Arthritis.
- In the U.S., the incidence of lyme disease has doubled since 1991, from about four cases per 100,000 people to eight per 100,000 people (300K cases per year)
- Peaks in May through July when ticks are most active.
- >90% of Lyme cases in the Northeast, Upper Midwest, and mid-Atlantic; however, the number of counties that are now deemed high-risk for lyme has increased >320% since the late 1990s.
- Climate is one reason (along with deer population surges, land use change, and human behavior) is why lyme disease is increasing.
- Tick distribution is affected by temperature, rainfall, and humidity.
- Tick abundance is greatest in moist, humid environments and declines during hot, dry periods.
- Warmer temperatures can also increase the developmental rate of ticks.
- With global warming, tick populations can move farther north, expanding their range and increasing the length of tick season.
- Tick numbers may also be affected by abundance of animal hosts, such as rodents (acorns!) and deer (hunting limits), which are also affected by climate.


