Clinical Recognition and Managment

Headshot of Anne Grossman, MD, FACP · Assistant Professor, Medical Education and Clinical Sciences
Anne Grossman
MD, FACP · Assistant Professor, Medical Education and Clinical Sciences
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How extreme heat harms the body

Humans maintain a core body temperature around 37°C (98.6°F) through thermoregulation (sweating, increased blood flow to skin). However, these cooling mechanisms can be overwhelmed in extreme environmental heat, especially with high humidity or dehydration.

Clinical comparison: heat exhaustion vs. heat stroke

Feature Heat exhaustion Heat stroke

Core temperature

Usually <40°C (104°F)

≥40°C (104°F)

Mental status

Normal (may be fatigued)

Altered: 

  • Confusion
  • Disorientation
  • Unconsciousness

Skin

  • Cool
  • Clammy
  • Heavy
  • Sweating

Often hot and dry (sweating may stop)

Symptoms

  • Weakness
  • Dizziness
  • Nausea
  • Headache
  • CNS dysfunction
  • Seizures
  • May progress to coma

Severity

Warning sign! Can progress to heat stroke, if untreated

Medical Emergency!

Heat exhaustion management

  • Move patient to cool environment and remove excess clothing.
  • Oral hydration (water or electrolyte solution).
  • Rest in supine position.
  • Monitor closely: Can progress to heat stroke if symptoms worsen.

Medical emergency: Heat Stroke Management

  • Recognition: Core temperature ≥40°C (104°F) and altered mental status.
  • Immediate Actions:
    • Call for emergency transport (911 or rapid EMS)
    • Begin rapid cooling immediately:
        • Ice water immersion (most effective if available).
        • Evaporative cooling: Mist skin with water and fans.
        • Ice packs to neck, armpits, and groin.
    • Stop cooling when temperature drops to 38–39°C (avoid overcooling).
    • Monitor for complications: Organ damage can occur (kidney, liver, heart); seizures possible.
  • Key Point: Speed of cooling is critical. Every minute of elevated core temperature increases risk of permanent organ damage and death.

Heat’s effects beyond direct illness

planetary-health-heat-impact-human-heat-strain-scaled-illustration
Tap to enlarge

Extreme heat also exacerbates underlying medical conditions:

  • Cardiovascular: Increased cardiac strain risking heart attacks, heart failure decompensation.
  • Respiratory: Worsening of asthma, COPD.
  • Renal and Metabolic: Dehydration can precipitate acute kidney injury; diabetes management becomes more difficult.

During the PNW heat dome, many deaths were officially recorded as heat stroke, but many others were heart attacks or strokes in which heat was a contributing factor.

How extreme heat affects the body

This TED-Ed video (~5 min.) provides an animated explanation of the physiological effects of heat waves on the human body.

Question

A 78-year-old patient is brought to the ED during a heat wave. Temperature is 105.8°F (41°C), skin is hot and dry, and the patient is confused and disoriented. What is the most likely diagnosis?

This patient meets criteria for heat stroke: Core temperature ≥104°F (40°C) and central nervous system dysfunction (confusion/disorientation). This is a medical emergency requiring immediate aggressive cooling.

Image credits

Unless otherwise noted, images are from Adobe Stock.

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The 2021 Pacific Northwest Heat Dome

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Understand Vulnerable Populations