Bugs and Drugs review: March 25, 2025
Transcript of session 100:01:01.050 –> 00:01:03.019Skye McKennon (she/her): Hi, Connie and Joanna. 200:02:09.960 –> 00:02:12.609SMED 175 Podium: Dr. Mckinnon. Can you hear me? 300:02:12.610 –> 00:02:14.210Skye McKennon (she/her): Now I can. Hi! 400:02:14.514 –> 00:02:24.850SMED 175 Podium: I had to turn on my mic. Do you want to take over screen sharing for your slides, […]
Pharmacology review: March 13, 2025
Transcript of session 100:01:27.770 –> 00:01:31.919Skye McKennon (she/her): Hello! Good morning! Can I be heard in the main room 200:01:35.500 –> 00:01:36.900Skye McKennon (she/her): just testing. 300:01:37.780 –> 00:01:38.680SMED 175 Podium: Hi! Skye! 400:01:38.680 –> 00:01:43.140Skye McKennon (she/her): Perfect thanks. I just wanted to test before we got started. Perfect. 500:01:45.530 –> 00:01:47.560Skye McKennon (she/her): […]
Pharmacology reviews
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Autonomic Receptors
Structural family Functional families Receptor Physiological ligands Effectors, Transducers, Major functions G Protein Coupled Receptors (GPCR) Muscarinic receptors M1 Acetylcholine Gq-coupled Increased phospholipase C increased IP3, diacylglycerol, cytoplasmic calcium M2 Acetylcholine Gi-coupled Decreased adenylyl cyclase decreased cAMP M3 Acetylcholine Gq-coupled Increased phospholipase C increased IP3, diacylglycerol, cytoplasmic calcium Alpha-adrenergic receptors Alpha1 (α1) Epinephrine, norepinephrine Gq-coupled Increased […]
The Effects of the Autonomic Nervous System on Organ Systems
Sympathetic Parasympathetic Organ Target Actiona Receptorb Actiona Receptorb Eye Iris Radial muscle Contracts α1 — — Circular muscle — — Contracts M3 Ciliary muscle [Relaxes] β Contracts M3 Heart Sinoatrial node Accelerates β1, β2 Decelerates M2 Ectopic pacemakers Accelerates β1, β2 — — Contractility Increases β1, β2 Decreases (atria) [M2] Blood vessels Skin, splanchnic vessels […]
Cellular Receptors of Relevance to Therapeutics
This table provides a summary of the various types of cellular receptors that are drug targets.  Classes Subclasses or families Physiological ligands Transducers, principal effects, or ions G protein-coupled receptors (GPCRs)a Adhesion Frizzled Glutamate Rhodopsin Secretin Very large number of endocrine and paracrine factors, but other types of ligands as well G proteins  Gs: Adenylyl […]
Pharmacology
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Pharmacology Resources
Common drug stems This table provides common drug stems to quickly help you determine to which class a medication belongs. GO TO Monoclonal Antibody Naming Convention slides Handouts The following pharmacology handouts are graciously being shared with WSU College of Medicine students by Dr. John Szarek. If you would like to utilize these handouts, you […]
References
Books + Journals Chapter 6 Introduction to Autonomic Pharmacology, Katzung BG, Kruidering-Hall M, Tuan R, Vanderah TW, Trevor AJ. Katzung & Trevor’s Pharmacology: Examination & Board Review, 13e; 2021. Accessed: September 13, 2022. Leurs, R. et al. The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nature Reviews Drug Discovery 4, 107-120 (2005). All […]
Self-Assessment
Quiz Question A drug is an alpha-1 adrenergic receptor agonist. Which effect would you expect the drug to have on vascular smooth muscle? Question A drug is an alpha-1 adrenergic receptor antagonist. Which effect would you expect the drug to have on vascular smooth muscle? Question A drug is a beta-1 receptor agonist. Which effect […]