Autonomic Receptors

Headshot of Skye McKennon , PharmD, BCPS, CSM-GEI
Skye McKennon
PharmD, BCPS, CSM-GEI
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Headshot of Connie Remsberg, PharmD, PhD
Connie Remsberg
PharmD, PhD
Office: SAC 403R
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Structural family Functional families Receptor Physiological ligands Effectors, Transducers, Major functions

G Protein Coupled Receptors (GPCR)

Muscarinic receptors

M1

Acetylcholine

Gq-coupled

Increased phospholipase C increased IP3, diacylglycerol, cytoplasmic calcium

M2

Acetylcholine

Gi-coupled

Decreased adenylyl cyclase decreased cAMP

M3
Acetylcholine
Gq-coupled

Increased phospholipase C increased IP3, diacylglycerol, cytoplasmic calcium

Alpha-adrenergic receptors

Alpha1 (α1)

Epinephrine, norepinephrine

Gq-coupled

Increased phospholipase C increased IP3, diacylglycerol, cytoplasmic calcium

Alpha2 (α2)

Epinephrine, norepinephrine

Gi-coupled

Decreased adenylyl cyclase decreased cAMP

Beta-adrenergic receptors

Beta1 (β1)

Epinephrine, norepinephrine

Gs-coupled

Increased adenylyl cyclase increased cAMP

Beta2 (β2)

Epinephrine, norepinephrine

Gs-coupled

Increased adenylyl cyclase increased cAMP

Beta3 (β3)

Epinephrine, norepinephrine

Gs-coupled

Increased adenylyl cyclase increased cAMP

Ion channel

Ligand-gated ion channels

NN

Acetylcholine

Na+-K+ ion channel

Depolarizes, evokes action potential

NM

Acetylcholine

Na+-K+ ion channel

Depolarizes, evokes action potential