Introduction to vaccines
High-yield summary Types of vaccines Live Attenuated: Replicates, broad immune response, contraindicated in immunocompromised and pregnancy Inactivated: No replication, safer for immunocompromised and pregnancy Polysaccharide and Conjugate: Capsule-targeted, age-dependent response, T-cell independent/dependent Protein Subunit: Toxoids, VLPs, recombinant proteins Viral Vector: Recombinant expression in vivo, adenovirus/VSV Nucleic Acid: mRNA/DNA vaccines, e.g., COVID-19 vaccines  Immunology and […]
Other therapies
Albendazole (Albenza) Class(es) Anthelmintic Clinical use(s) FDA approved: echinococcosis, neurocysticercosis. Off-label/clinical use: Ascariasis, capillaria, clonorchiasis, giardiasis, microsporidia (HIV), hymenolepis nana infection, loa loa, trichuriasis. Mechanism(s) of action Causes parasitic death by binding to colchicine-sensitive site of beta tubulin inhibiting their polymerization into microtubules. Key adverse effects Abdominal pain, headache, abnormal liver function tests, N/V, SJS. […]
Tuberculosis
This is the LP for this topic. Include Antituberculars on this page. This URL may need to change. Public Health may want to link to this page.
Micro-ID sorted by systems
rename this page eventually Could link to these from Learning site system LPs put link to this page on the compendium LP and possibly the thread LP Pages to start from: Disease location page is almost system based Overview of parasites is almost system based Outline of parasite diseases and organism according to site/specimen is […]
Other antibiotics
Clindamycin (Cleocin) Class(es) Lincosamide Clinical use(s) FDA approved: Bacterial disease (severe) Including susceptible infections due to anaerobic and aerobic gram positive organisms. Off-label/clinical use: Acne vulgaris (topical). Mechanism(s) of action Inhibits protein synthesis at the level of the 50S ribosomal subunit. Key adverse effects The most common reported AE is mild to moderate morbilliform-like skin […]
Cephalosporins
Cephalexin (Keflex) Class(es) 1st-generation cephalosporin Clinical use(s) FDA approved: Skin and soft tissue infection, osteomyelitis. Off-label/clinical use: Prophylaxis for bacterial endocarditis. Mechanism(s) of action Binds to penicillin binding proteins in cell wall membrane. Key adverse effects C. diff–associated diarrhea (CDAD), seizures (high doses especially in renal impairment) Key drug/food interactions Concurrent use of loop diuretics […]
Antituberculars
Isoniazid (INH, Nydrazid) Class(es) Antitubercular agent. Clinical use(s) FDA approved: Active tuberculosis (HIV and non-HIV); inactive tuberculosis (HIV and non-HIV). Off-label/clinical use: Atypical mycobacterial infection; determination of acetylation rate. Mechanism(s) of action Bactericidal. Inhibits synthesis of mycoloic acids, an essential component of the bacterial cell wall. Key adverse effects Increased liver enzymes, neuropathy, neurotoxicity. Key […]
Penicillin beta-lactams
Penicillin (PCN) Class(es) Penicillins/Beta-Lactams. Clinical use(s) FDA approved: Syphilis, anthrax, listeria infections, meningococcal infections, pasteurella, serious gram-positive infections. Off-label/clinical use: CAP (children), group B strep, osteomyelitis, SSTI. Mechanism(s) of action Bactericidal. Inhibits bacterial cell wall synthesis during active multiplication. Key adverse effects Nausea, vomiting, diarrhea, seizure (rare). Key drug/food interactions Tetracyclines (may ↓ effectiveness)Food (may […]
Plasmodium species comparison chart
This is an optional study guide. Details for P. malariae have been completed for you as an example.  P. falciparum P. vivax P. ovale P. knowlesi P. malariae Predominant geography     Rare. Temperate and subtropical Erythrocyte target     Senescent cells only Interval between merozoite release from RBCs  […]
Plasmodium/Malaria
This is the LP for this topic. The content is also on the Protozoa page. It needs to go on its own malaria content page and then delete it from the Protozoa page (feed it with a Posts query) and delete it from here (also feed it with a Posts query). This URL may need […]