Lesson 3. Risk: Exposure to Disease

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Headshot of Robert (Bob) Lutz, MD, MPH · Public Health course director
Robert (Bob) Lutz
MD, MPH · Public Health course director
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Headshot of Judi Marcin, MD, MFA, Faculty
Judi Marcin, MD, MFA
Faculty
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Headshot of Chaise Zozaya, MPH, MBA · Course director
Chaise Zozaya
MPH, MBA · Course director
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Table of Contents

Exposure to disease

Required reading

Clinical Epidemiology: The Essentials, Chapter 6, (P92–110)

  1. When experiments are not possible or ethical. 
  2. Cohorts. 
  3. Cohort studies. 
  4. Prospective and historical cohort studies. 
  5. Prospective cohort studies. 
  6. Historical cohort studies using medical databases. 
  7. Case-cohort studies. 
  8. Advantages and disadvantages of cohort studies. 
  1. Absolute risk. 
  2. Attributable risk. 
  3. Relative risk. 
  4. Interpreting attributable and relative risk. 
  5. Population risk. 
  1. Extraneous variables. 
  2. Simple descriptions of risk. 
  1. Working definition. 
  2. Potential confounders. 
  3. Confirming confounding. 
  1. Randomization. 
  2. Restriction. 
  3. Matching. 
  4. Stratification. 
  5. Standardization. 
  6. Multivariable adjustment.
  7. Overall strategy for control of confounding. 

From disease to exposure

Required reading

Clinical Epidemiology: The Essentials, Chapter 7, (P111–125)

  1. The source population. 
  2. Selecting cases. 
  3. Selecting controls. 
  4. The population approach. 
  5. The cohort approach. 
  6. Hospital and community controls. 
  7. Multiple control groups. 
  8. Multiple controls per case. 
  9. Matching. 
  10. Measuring exposure. 
  11. Multiple exposures. 
  1. Odds ratio calculation. 
  2. Odds ratio as an indirect estimate of relative risk. 
  3. Odds ratio as a direct estimate of relative risk. 

Go to Lesson 3 Knowledge Check

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