Knowledge Check

Headshot of Dawn Elise DeWitt, MD, MSc, CMedEd, MACP, FRACP, FRCP-London · Senior Associate Dean, Collaboration for InterProfessional Health Education Research & Scholarship (CIPHERS)
Dawn Elise DeWitt
MD, MSc, CMedEd, MACP, FRACP, FRCP-London · Senior Associate Dean, Collaboration for InterProfessional Health Education Research & Scholarship (CIPHERS)
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While this knowledge check is “open book,” the best way to learn is to practice spaced-repetition “free recall.” So try to answer these questions without looking.

The class of medication indicated for mild Alzheimer Disease.

Acceptable response

Acetylcholinesterase inhibitors

The class/name of medication indicated for moderate-severe Alzheimer Disease.

Acceptable response

NMDA receptor antagonist, memantine

CSF proteins used for diagnosis of Alzheimer Disease.

Acceptable response

Beta Amyloid 43; Tau and P-Tau

Vitamin deficiency most likely to cause dementia in a patient on omeprazole (PPI).

Acceptable response

Vitamin B12

Dementia within one year of Parkinson Disease diagnosis.

Acceptable response

Lewy body dementia

Early onset personality change and excessive/obsessive-compulsive behavior.

Acceptable response

Frontotemporal dementia

Contraindication to acetylcholinesterase inhibitors.

Acceptable response

Bradycardia
(conduction disorders)

Gait disturbance, incontinence, ventricular enlargement.

Acceptable response

Normal pressure hydrocephalus

Neurological motor disease associated with frontotemporal dementia.

Acceptable response

ALS (in 25%)

Cognitive screening test for dementia.

Acceptable response

MoCHA (and others)

MRI finding consistent with Alzheimer dementia.

Acceptable response

Volume loss, especially in the hippocampus